Off-label Benefits of Modafinil

Known under various names, including Modalert and Alertec, Modafinil was first marketed as Provigil as a treatment for EDF or Excessive Daytime Sleepiness. But it is now prescribed by doctors for a variety of lifestyle benefits. What makes Modafinil unique is that it is in a different class of medications from all other stimulants. Amphetamines are typically heart-stomping drugs that lead to abuse and addiction. Modafinil is not an amphetamine and bring along that unwelcome bagage. Modafinil is classed as a eugeroic drug. Eugeroic means 'good arousal.' Modafinil keeps you alert and awake without running the health risks of amphetamines.


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Modafinil is officially only approved for narcolpesy. But many doctors are prescribing it for a variety of “lifestyle” benefits as well as various other clinical conditions. Here are some of the lifestyle benefits and conditions Modafinil is used for:

  • Fatigue caused by high-pressure jobs requiring long hours
  • Fatigue in people who need to be alert e.g students cramming for exams
  • Travellers with Jet lag
  • Withdrawal from cocaine addiction
In addition to narcolepsy, doctors are also prescribing Modafinil for many other medical conditions:
  • Age-related memory decline
  • Fatigue caused by chemotherapy treatment for cancer patients
  • Fatigue experienced by persons suffering from diseases such as multiple sclerosis
  • Attention deficit disorder
  • Memory problems associated with Alzheimer’s
  • Grogginess after anaesthetics
  • Sleepiness caused by other prescription medications

Clinical trials are also underway to determine the effectiveness of Modafinil to treat conditions other than EDS associated with narcolepsy. These trials hope to use Modafinil to benefit sufferers of OSAHS (Obstructive Sleep Apnea/hypopnoea syndrome and SWSD (Shift Work Sleep Disorder).